Using detailed maps of molecular shapes and the electrical charges surrounding them, researchers at National Jewish Health have discovered how the metal beryllium triggers a deadly immune response in the lungs.
In the July 3, 2014, issue of the journal Cell John Kappler, PhD, and his colleagues show how a genetic susceptibility to the disease creates a molecular pocket in an immune system protein, which captures beryllium ions and triggers an inflammatory response in the lungs. The findings describe for the first time an immune response that lies somewhere between classic forms of allergic hypersensitivity and auto-immunity.
"The immune system does not actually 'see' beryllium," said Dr. Kappler. "The beryllium changes the shape of otherwise innocuous self-peptides so that T cells recognize them as foreign and dangerous."
Beryllium is a relatively rare metal whose unique combination of strength and lightness makes it invaluable for various industrial uses, ranging from triggers for nuclear bombs to satellite components, computers and cell phones. It can cause disease when people who work with the metal inhale particles that become lodged in the lungs. People who develop chronic beryllium disease can have varied courses of disease, from stable with medications to progressive lung damage and death.
Not everyone who works with the metal becomes ill. About 85 percent of people who develop chronic beryllium disease have an immune system protein known as HLA-DP2. Cells throughout the body use this molecule to tell the immune system what is going on inside of them. HLA-DP2 sits on the cell surface holding small protein fragments taken from the cell's interior. Immune system sentinels known as T cells bump against HLA-DP2 and its displayed protein fragment. If the protein fragment is derived from the body's own proteins, the T cell ignores it; if it is a foreign peptide, say from a bacterium, virus or other pathogen, the T cell sounds the alarm and triggers an immune response.